Título / Title

SILICONE OIL DROPLETS IN EYES TREATED WITH INTRAVITREAL INJECTION

Introdução / Purpose

To assess the number of eyes with silicone oil in the vitreous after intravitreal injection and its association with the number of previous procedures.

Material e Método / Methods

This cross-sectional study was divided into 2 groups: 1) treatment group- eyes previously subjected to an intravitreal injection of antiangiogenic; 2) control group- no previous injection. All eyes underwent slit-lamp and ultrasound examination. ImageJ software was used to quantify the area of silicone oil in comparison to the area of the vitreous (index of silicone oil – IOS).

Resultados / Results

Sixty-seven eyes (30 controls) were included. Slit-lamp examination found silicone oil droplets in 25 out of 37 (67.57%) treated eyes and in none of the control group. Similarly, ultrasonography identified silicone oil in 28 out of 37 (75.68%) treated eyes and in 1 out of 30 (3.33%) controls. Considering only slit-lamp findings, multiple logistic regression disclosed an odds-ratio (OR) of 18.44 (95% CI: 0.60 - 560.03, P=0.094) for silicone oil in previously treated eyes and 1.36 (95% CI: 1.04 – 1.77, P=0.024) for silicone oil according to the number of previous injections. Considering ultrasound findings, multiple logistic regression disclosed an OR of 32.07 (95% CI: 3.72 – 275.96, P=0.002) for silicone oil in previously treated eyes and 1.11 (95% CI: 0.95 – 1.29, P=0.180) for silicone oil according to the number of previous injections. IOS was higher in treated eyes (2.69±2.55%) than in controls (0.41±0.43%), P=0.0006. Spearman’s correlation test (0.61; P<0.0001) showed that the greater the number of injections, the higher the IOS.

Discussão e Conclusões / Conclusion

Silicone oil droplets were found in the majority of the eyes previously submitted to an intravitreal injection of antiangiogenic. The greater the number of injections, the higher the likelihood of finding silicone oil as well as its amount. An improvement in the technique of injection should be considered.

Palavras Chave

ultrasonography; intravitreal injection; silicone oil droplets; syringe.