Abstract General Information


Título / Title

A NEW DYE BASED ON ANTHOCYANINS FROM THE ACAI FRUIT (EUTERPE OLERACEA) FOR CHROMOVITRECTOMY IN HUMANS: CLINICAL TRIAL RESULTS

Introdução / Purpose

To test the applicability of the acai dye at a 25% concentration for identifying the posterior hyaloids and internall limiting membranes (ILMs) during pars plana vitrectomy (PPV) in human eyes with macular holes (MHs).

Material e Método / Methods

This study included 25 patients with chronic idiopathic MHs. The exclusion criteria included glaucoma, previous significant ocular conditions, and previous ocular surgeries except uncomplicated cataract. Ten surgeons performed 23-gauge four-port PPV, phacoemulsification, posterior hyaloid detachment, ILM peeling guided by dye staining, and perfluoropropane injection. The patients remained prone for 5 days postoperatively. The patients were evaluated postoperatively after 1, 30, and 180 days. The surgeons completed a questionnaire regarding the dye’s staining abilities.

Resultados / Results

The posterior hyaloids and ILMs stained purple in all eyes. The final best-corrected visual acuity improved significantly (p < 0.001) from preoperatively (1.37 ± 0.29) to 180 days postoperatively (1.05 ± 0.43). The MHs closed in 76% of eyes.

Discussão e Conclusões / Conclusion

The acai dye at a 25% concentration identified posterior hyaloids and ILMs during PPVs in humans. Dye toxicity was unlikely.

Palavras Chave

Acai dye . Internal limiting membrane . Pars plana vitrectomy . Posterior hyaloid . Toxicity

Area

SURGICAL RETINA

Institutions

UNIFESP - São Paulo - Brasil

Authors

Rafael Ramos Caiado, Cristiane Peris, Eduardo Buchele Rodrigues, Michel Eid Farah, André Maia, Octaviano Magalhães Junior, Eduardo Novais, Acácio Souza Lima-Filho