Título

FLUORESCEIN ANGIOGRAPHY FINDINGS IN CHILDREN WITH CONGENITAL ZIKA SYNDROME

Introdução

To evaluate the retinal and vasculature changes in infants with congenital Zika syndrome (CZS) using fluorescein angiography (FA).

Métodos

This consecutive case series included six infants with CZS. FA and color fundus imaging were performed under general anesthesia in both eyes of all infant using a contact wide-field digital imaging system. All color fundus images were obtained using a 130o field of view lens and the FA images were captured using either a 130o or 80o field of view lens. The IgM antibody capture enzyme-linked immunosorbent assay was positive for ZIKV in the cerebrospinal fluid samples of all infants. Other congenital infections were ruled out.

Resultados

The mean ± standard deviation (SD) age of the infants at the time of examination was 1.4 ± 0.1 years (range, 1.3-1.5 years). Contact fundus photographs showed macular abnormalities in seven eyes (58%) and retinal vasculature changes in two eyes (17%). FA detected macular abnormalities in all 12 eyes (100%) and retinal vasculature changes in five eyes (42%). The main retinal vasculature changes were peripheral avascularity in five eyes (42%) and microvasculature abnormalities in three eyes (25%).

Conclusões

FA may be an important tool for detecting subtle macular and retinal vasculature changes in CZS.

Palavras Chave

Zika virus; Congenital Zika Syndrome

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