Título

MANTLE CELL LYMPHOMA CAUSING BILATERAL ACUTE LOW VISION

Introdução

Mantle cell lymphoma (MCL) comprises 5% of non-
Hodgkin lymphoma. In general, patients are typically
Caucasian (about 2:1), male (about 2.5:1), and elderly
(median age of onset, 68 years), and they usually present
themselves as an extensive disease, including widespread
lymphadenopathy, bone marrow involvement,
splenomegaly, circulating tumor cells, and bowel
infiltration.1 Central nervous system (CNS) involvement is
an unusual form of extranodal involvement in the course of
MCL..

Métodos

It was a case of Mantle Cell Lymphoma with tumoral infiltration of
CNS as a cause of bilateral acute low vision. The patient arrived
from the emergency room of a university hospital (UNIFESP).

Resultados

Optic disc edema may be seen in a number of conditions; increased intracranial pressure (ICP), optic neuritis,
tumoral causes (hematologic and metastasis cancer) ischemic optic neuropathy, toxic and nutritional optic
neuropathies are possible etiologies. Our patient because of the bilateral impairment is mandatory to exclude ICP
first. Metastasis can reach the optic nerve via the choroid, by vascular dissemination, by invasion from the orbit, and
through the central nervous system.

Neuroimaging is crucial in patients suspected of infiltrative optic neuropathy due to cancer. Our patient had MRI

findings an optic diffuse nerve enlargement that is more common signal in MRI.

Conclusões

MCL is a very aggressive subtype of non-Hodgkin lymphoma and is unique among lymphomas in its clinical,
biologic, and genetic properties. Nearly 70% of cases are diagnosed in advanced stages of the disease and most
cases show a relatively aggressive course. Median life expectancy ranges from 3 to 7 years. Because of its
unresponsiveness to medical treatment as well as its aggressive nature, MCL is generally considered incurable.

Palavras Chave

Mantle Cell Lymphoma bilateral acute low vision

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