Title

USE OF BEVACIZUMAB IN EYE METASTASIS OF BRONCHIC EPIDERMOID CARCINOMA: A CASE REPORT

Introduction

We describe a case of uveal metastasis from bronchial squamous cell carcinoma with good response to intravitreal use of Bevacizumab, with a 6-month follow-up.

Methods

Case report from medical record analysis

Results

A 57-year-old male patient was admitted to the DE of the Ophthalmology Service at UNICAMP with a complaint of low visual acuity and pain in the right eye that started 7 days ago. Previous diagnosis of squamous cell carcinoma of the lung Patient had BCVA of 0.1 in OD. Biomicroscopy showed 2+ anterior chamber reaction and a whitish nodular lesion in the lower region of the iris, with expansion to lower camerular angle. Mydriasis examination showed a lesion in the lower pupillary border posterior to the iris. Fundus examination was unremarkable. Ultrasound identified a hyperechogenic mass in the region of the ciliary body, measuring 8.4 mm of base and 6.5 mm of thickness, with an irregular aspect, invading the posterior region of the iris A hypothesis of metastasis of lung squamous cell carcinoma to the ciliary body with iris involvement and camerular angle was made, and application of Bevacizumab 1.25mg / 0.05mL intravitreal was performed. 15 days after administration, BCVA improved to 0.3. Due to clinical improvement, a new injection was performed. 30 days after the first injection, the patient reported absence of pain, with BCVA of 0.5, absence of anterior chamber reaction and lesion with aspect and size maintained. Chosen to maintain the treatment with monthly injections. After a 6-month follow-up, the patient maintains a stable clinical course with BCVA of 0.5, without a significant increase in the size of the lesion

Discussion

Metastasis are the most common eye malignancy and, therefore, have great clinical relevance. Our report shows a successful case of treatment of metastatic carcinome using intravitreal bevacizumab biweekly until clinical control and monthly maintenance dose that demonstrated clinical and anatomical tumor stabilization during the 6-month follow-up.

Keywords

Ocular metastasis, Bevacizumab, Lung cancer

Area

CLINICAL CASE

Authors

Gustavo de Carvalho Pazeto, ROBERTO DOS REIS, Camillo Gusmão, Guilherme Valadares Gomes, Delma Regina Huarachi, Fernando Rodrigo Pedreira Chaves, Maurício Abujamra Nascimento, Andrea Mara Torigoe