Title

Central serous chorioretinopathy associated with isotretinoin.

Introduction

Introduction:purpose to report a case bilateral excessive subretinal fluid during the use of isotretinoin.

Methods

A 17 years old male patient presented to our clinic with blurred vision both eyes 1 week ago. He had been using oral isotretinoin for the last 2 weeks, as prescribed by his dermatologist to treat acne vulgaris.On examination visual acuity was 20/40 in both eyes. Biomicroscopic examination revealed blepharitis and meibomitis.Dilated fundus examination revealed lobulated shallow serous retinal detachment temporal of the fóvea bilateral. On fundus fluorescein angiography, multiple hyper fluorescent spots were seen in the temporal of the fovea in the early phases. Late phase phase revealed persistent and increased hyper fluorescence and serous macular detachment. OCT demonstrated neurosensory retinal detachment with subretinal fluid both eyes. results: One month later, visual acuity increased to 20/20 and oct demonstrate totally recovered with no residual sub retinal fluid after the discontinuation of isotretinoin.

Results

In our literature search, the serous retinal detachment caused by isotretinoin has been described in only 2 scientific studies, this would therefore be the third report of this type of retinal lesion caused by oral isotretinoin

Discussion

We found only 2 cases described in the literature with suspicion of Serous retinal detachment secondary to the use of oral Isotretinoin. We believe that isotretinoin can act just like corticosteroids, increasing the permeability of EPR, Bruch's layer and choriocapillaries. However, no systemic or ocular disorders were found in the patient in question. The relationship between stressed patients and the accumulation of subretinal fluid is well known, in the case presented here, the patient did not report that he was in stress activities and did not complain about stress that justifies the retinal injury. [5]

Keywords

isotretinoin

Area

CLINICAL CASE

Authors

ALEXANDRE TAGLIARI CESTARI, PAULO KIN TAKARA